I don't think that the gear ratio is critical in this matter. If we look at the top speeds from qualifying at the start of the season, when Mercedes was expected to have the best DRS on the grid, they didn't have any significant top speed advantage. For example, in China Mercedes were 1st and 3rd fastest during qualifying, but their top speeds were not particularly high:
http://www.formula1.com/results/season/ ... _trap.html
In Monaco Mercedes were 1st and 3rd again, but they didn't have higher top speed than their closest rivals. You can look at other tracks at the start of the season without seeing any significant difference in top speed. This leads me to think that if Mercedes indeed had the most efficient DRS, the benefit was not in having a higher top speed, but at reaching the top speed sooner (and thus keeping it for longer). It's the same reason why KERS is deployed as soon as possible onto a straight, as this will give a speed advantage all the way until breaking. If you deploy KERS towards the end of a straight, you may reach a higher top speed at the end, but you won't gain much time from it because you have to break for the corner immediately after. So I don't think the gear ratio is of importance. The benefit lies mainly in better acceleration, not in higher top-speed. Just as with KERS.
Based on this reasoning, the DRS-zones should preferably be located at the start of a straight after a slow or medium speed corner, not at the end. So for example at Spa, where the DRS-zone was located after Eau Rouge, it didn't really make a big difference, because the cars were already close to top speed (rpm limiter) when they entered the zone.
Ideally, they should combine DRS with an 8th gear which is only permitted during DRS deployment. That would aid overtaking more efficiently. If everyone had an 8th gear that was not permitted used during qualifying, the first 7 gears would have to be chosen more or less as they are today. And the 8th gear would ensure the car trying to overtake to have a higher top speed than the car being overtaken. However, with the new engines in 2014, the gear ratios might not be critical anymore.