I think the leaning aspect is a whole different can of worms. It would be interesting to see how much it would help or hinder aerodynamics. Sure, the floor and wings are no longer parallel to the ground, but one side would benefit from lower ground clearance. If this doesn't totally destroy aero performance on the high side, you'd possibly get more ground effect w/ the center of lift shifted slightly inward, adding more weight to the inside wheels in addition to shifting CoG slightly (by leaning).
Regarding tire wear (and ignoring leaning as an option): would positive camber on the inside wheel really help that much? It would still be unloaded w/ a smaller contact patch and same opportunity for flat spotting.