xpensive,
A flat, opposed (180deg V) 4 cylinder engine and a conventional (less than 180deg V) V4 engine differ mostly in how their crank pins are arranged. A flat 4 will normally use 4 crank pins, with adjacent pins spaced 180deg apart in order to achieve dynamic balance. On the other hand, a 90deg V4 might use only 2 crank pins spaced 180deg apart, with rods from opposing cylinder banks running side-by-side on a common crank journal.
As for the differences between a conventional V12 and a flat 12, the cranks are usually identical. This is because both engines are essentially two in-line 6 cylinder engines with a common crank. Since an in-line 6 with equally spaced crank pins has perfect dynamic balance, the V angle of a V12 is not so important with regards to balance.
Hope that was helpful.
Terry