ak07,
Deflections in the cylinder head and block structures with a stressed engine chassis are a big concern. Misalignment of block main bearing bores, cylinder bores going out-of-round, and misalignment of cam journals in the heads are all problems with an engine subjected to high chassis loads.
The problem also gets worse with longer engines. Many years ago when Ferrari first ran their N/A 3.5L V12, they made the blocks from thin wall cast iron to increase their stiffness.
riff_raff