From Wikipedia -
http://en.wikipedia.org/wiki/CAD
"First commercial applications of CAD were in large companies in the automotive and aerospace industries, as well as in electronics. Only large corporations could afford the computers capable of performing the calculations. Notable company projects were at GM (Dr. Patrick J.Hanratty) with DAC-1 (Design Augmented by Computer) 1964; Lockheed projects; Bell GRAPHIC 1 and at Renault (Bezier) – UNISURF 1971 car body design and tooling."
People are still designing full single seater race cars without CAD now, see most ametuers!