Yes/No/Maybe.
I don't think NA is ever going to return in F1 and a 3.9li V12 is just pipe dream. Even Indycar is going to some variation on a hybrid. The future, at least until the Formula E exclusive electric licence runs out, looks like 2 stroke with some sort of bio fuel. Which could be very interesting or it could be just as dire as the current power unit.
Proper manual gearboxes would be interesting... it's something Frank Dernie talks about a lot, i.e. many of the overtakes in the past mostly being a result of driver error missing a gear change. Over-revs or carelessness meant lesser/inexperienced drivers would break their cars too. You could also have a foot-cam of some heel-and-toe action
teams won't go for it though, certainly not with the limit per-season.
Cable throttle again is something which could lead to driver error, but just isn't feasible with the hybrid systems. Having a linear pedal-torque map makes the cars/power easier to drive. Not easy, but easier.
Active aero and fans could be an interesting development. Especially as the purpose of the fan is to suck away the boundary layer, it should increase energy in the wake.
The Gordon Murray add lightness approach should be at the forefront of the rule makers minds, but they keep adding weight to already tubby cars.
So while I agree with the opinion F1 probably should go more manual and simpler in it's execution, it wont. I'd love Red Bull to get tired of F1 and start their own championship along that principal, but they wont.